| 5242 | 29 | DAVID E CONGALTON DDS PLC | 3:27:21 | 7:55 | 48:54 | 1:15:23 | 1:34:08 | 2:22:50 | 3:03:54 | 1 | Masters Mixed | David Congalton Tammi Congalton |
| 5244 | 30 | VCCYF | 3:28:13 | 7:57 | 50:22 | 1:19:27 | 1:39:02 | 2:29:57 | 3:04:17 | 2 | Masters Mixed | William Copeland Sarah Guth Je |
| 5002 | 42 | TEAM CHOCOLATE MILE | 3:34:21 | 8:11 | 48:23 | 1:21:50 | 1:45:12 | 2:34:48 | 3:10:47 | 3 | Masters Mixed | Amy Craft Ahrens Danielle Galla |
| 5180 | 54 | ARWHAL RETURNS | 3:39:20 | 8:22 | 45:11 | 1:24:01 | 1:50:27 | 2:49:12 | 3:18:55 | 4 | Masters Mixed | Christine Haines John Haines L |
| 5178 | 74 | SOUTH END SPRINTERS | 3:45:42 | 8:37 | 58:15 | 1:37:07 | 2:04:53 | 2:52:43 | 3:24:10 | 5 | Masters Mixed | Eric Boehm Kirstin Boehm Lucia |
| 5196 | 77 | LETS DO THIS!! | 3:46:27 | 8:39 | 47:22 | 1:22:36 | 1:46:35 | 2:37:27 | 3:20:21 | 6 | Masters Mixed | Bryan Cho Raymond Coffey Jason |
| 5008 | 87 | JESSICA'S HAND-OFF | 3:49:21 | 8:45 | 1:02:23 | 1:33:33 | 1:55:05 | 2:42:35 | 3:19:35 | 7 | Masters Mixed | Aimee Boucher Sami Bousnina Ma |
| 5117 | 92 | GOOD2GO | 3:49:59 | 8:47 | 56:06 | 1:34:30 | 2:01:02 | 2:48:26 | 3:20:15 | 8 | Masters Mixed | Gregory Gaudreau Laurie Gaudrea |
| 5316 | 101 | BOATHUNKS.COM | 3:51:29 | 8:50 | 1:03:06 | 1:43:30 | 2:12:05 | 2:57:24 | 3:28:23 | 9 | Masters Mixed | Amanda Cronin Brian Cronin Dan |
| 5095 | 110 | RUNNING FOR GUINNESS | 3:53:45 | 8:55 | 49:23 | 1:22:20 | 1:45:06 | 2:37:32 | 3:22:00 | 10 | Masters Mixed | Kim Corrow Kristy Corrow Derek |
| 5336 | 137 | SEM RUN | 4:00:03 | 9:10 | 1:03:35 | 1:39:00 | 2:01:16 | 2:53:17 | 3:32:53 | 11 | Masters Mixed | Jacquelyn Semler Joan Semler S |
| 5140 | 166 | WILD ROSE CIRCLE CHEETAHS | 4:04:15 | 9:19 | 55:37 | 1:32:37 | 1:57:35 | 3:00:33 | 3:37:09 | 12 | Masters Mixed | Chris Auer Jay Guyette Fenn Ri |
| 5029 | 171 | YET AGAIN | 4:05:39 | 9:23 | 49:31 | 1:23:49 | 1:47:53 | 2:55:30 | 3:36:02 | 13 | Masters Mixed | Rebecca Allen Ken Grillo Tammy |
| 5057 | 172 | EXEMPLARY RUNNERS | 4:06:08 | 9:24 | 50:42 | 1:26:34 | 1:51:25 | 2:52:43 | 3:35:00 | 14 | Masters Mixed | Megan Meadows Cat Morgan Cathe |
| 5232 | 179 | MELROSE VARSITY | 4:07:33 | 9:27 | 51:21 | 1:31:35 | 2:02:03 | 3:02:55 | 3:42:00 | 15 | Masters Mixed | Leanne Dennison Robyn Gentile |
| 5100 | 184 | PAUL FRANK + COLLINS | 4:08:41 | 9:30 | 1:02:05 | 1:31:39 | 1:51:03 | 2:46:18 | 3:28:57 | 16 | Masters Mixed | Doug Brines Matt Ferrigno Shan |
| 5211 | 199 | HOPS AND LACES | 4:11:29 | 9:36 | 51:19 | 1:28:51 | 1:56:43 | 2:51:18 | 3:27:07 | 17 | Masters Mixed | Leslie Bailey Andrew Benbow Ni |
| 5293 | 207 | SYNERGIE2.2 | 4:13:44 | 9:41 | 1:05:01 | 1:47:29 | 2:16:02 | 3:10:27 | 3:49:28 | 18 | Masters Mixed | Caroline Boisclair Patrice Cuil |
| 5289 | 219 | SCATTERED FROST | 4:16:06 | 9:47 | 42:32 | 1:22:40 | 1:53:51 | 2:49:49 | 3:37:18 | 19 | Masters Mixed | Liz Bushey Jessica Decarolis J |
| 5105 | 253 | THE WRIGHT STUFF | 4:29:09 | 10:16 | 1:00:43 | 1:33:51 | 1:55:47 | 3:01:48 | 3:48:46 | 20 | Masters Mixed | Katherine Kelly Patrick Kelly |
| 5326 | 285 | THE BIKING BAKERS | 4:40:56 | 10:43 | 1:04:21 | 1:49:03 | 2:19:31 | 3:19:41 | 4:06:49 | 21 | Masters Mixed | Bridget Logan Douglas Logan Ja |
| 5167 | 296 | JJMCC2022 | 4:46:29 | 10:56 | 1:00:35 | 1:41:02 | 2:08:59 | 3:06:45 | 4:04:32 | 22 | Masters Mixed | Maryellen Copping Cris Cote Ja |
| 5318 | 324 | CELEBRATING #75 | 5:19:58 | 12:13 | 58:29 | 1:44:29 | 2:19:41 | 3:44:36 | 4:45:16 | 23 | Masters Mixed | Gail Johnson Nathan Johnson Gr |
| 5308 | 338 | LAKE'S LOPERS | | | 39:03 | | | 3:06:12 | | 0 | Masters Mixed | Joshua Boeltz Jean Corday Andr |
| 5284 | 341 | POTATO HOES | | | 1:05:59 | 1:58:42 | 2:36:53 | 3:48:38 | | 0 | Masters Mixed | Alicia Castro-Mays Kathleen Cha |
| 5233 | 342 | GO THE DISTANCE | | | 57:22 | 1:40:39 | 2:14:42 | | | 0 | Masters Mixed | Megan Hack Brian Sprague Nicho |